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High modulus biodegradable polyurethanes for vascular stents: Evaluation of accelerated in vitro degradation and cell viability of degradation products

机译：用于血管支架的高模量可生物降解聚氨酯：评估降解产物的加速体外降解和细胞活力

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We have recently reported the mechanical properties and hydrolytic degradation behavior of a series of NovoSorb™ biodegradable polyurethanes (PUs) prepared by varying the hard segment (HS) weight percentage from 60 to 100. In this study, the in vitro degradation behavior of these PUs with and without extracellular matrix (ECM) coating was investigated under accelerated hydrolytic degradation (phosphate buffer saline; PBS/70°C) conditions. The mass loss at different time intervals and the effect of aqueous degradation products on the viability and growth of human umbilical vein endothelial cells (HUVEC) were examined. The results showed that PUs with HS 80% and below completely disintegrated leaving no visual polymer residue at 18 weeks and the degradation medium turned acidic due to the accumulation of products from the soft segment (SS) degradation. As expected the PU with the lowest HS was the fastest to degrade. The accumulated degradation products, when tested undiluted, showed viability of about 40% for HUVEC cells. However, the viability was over 80% when the solution was diluted to 50% and below. The growth of HUVEC cells is similar to but not identical to that observed with tissue culture polystyrene standard (TCPS). The results from this in vitro study suggested that the PUs in the series degraded primarily due to the SS degradation and the cell viability of the accumulated acidic degradation products showed poor viability to HUVEC cells when tested undiluted, however particles released to the degradation medium showed cell viability over 80%.
机译：我们最近报道了通过改变硬链段（HS）重量百分比从60到100制备的一系列NovoSorb™可生物降解聚氨酯（PU）的机械性能和水解降解行为。在这项研究中，这些PU的体外降解行为在加速水解降解（磷酸盐缓冲盐水； PBS / 70°C）条件下研究了有无细胞外基质（ECM）涂层。检查了在不同时间间隔的质量损失以及水降解产物对人脐静脉内皮细胞（HUVEC）活力和生长的影响。结果表明，HS含量在80％以下的PU完全崩解，在18周时没有可见的聚合物残留，并且降解介质由于软链段（SS）降解产物的积累而变成酸性。不出所料，HS最低的PU降解最快。当未经稀释测试时，累积的降解产物对HUVEC细胞显示出约40％的活力。然而，当溶液稀释至50％或以下时，存活率超过80％。 HUVEC细胞的生长与组织培养聚苯乙烯标准品（TCPS）观察到的相似但不相同。这项体外研究的结果表明，该系列中的PU主要由于SS降解而降解，并且在未稀释的情况下进行测试时，所积累的酸性降解产物的细胞活力对HUVEC细胞显示出较差的活力，但是释放到降解介质中的颗粒却显示出生存能力超过80％。

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